MC1742 | HDAC inhibitor | Probechem Biochemicals

Chemical Structure : MC1742

CAS No.: 1776116-74-5

MC1742 (MC-1742)

Catalog No.: PC-27699Not For Human Use, Lab Use Only.

MC1742 is a potent HDAC inhibitor with IC50s of 0.1 μM, 0.11 μM, 0.02 μM, 0.007 μM, 0.61 μM, 0.04 μM and 0.1 μM for HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, HDAC10 and HDAC11, respectively, also potently reactivate HIV from latency.

Packing	Price	Stock
5 mg	$88	In stock
10 mg	$128	In stock
25 mg	$198	In stock
50 mg		Get quote
100 mg		Get quote

Get Quotation Now

* Please select Quantity before adding items.

or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Biological Activity

MC1742 is a potent HDAC inhibitor with IC50s of 0.1 μM, 0.11 μM, 0.02 μM, 0.007 μM, 0.61 μM, 0.04 μM and 0.1 μM for HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, HDAC10 and HDAC11, respectively, also potently reactivate HIV from latency with EC50 of 350 nM.
MC1742 increases acetyl-H3 and acetyl-tubulin levels and inhibits cancer stem cells growth.
MC1742 induces growth arrest, apoptosis, and differentiation in sarcoma cancer stem cells (CSCs).
MC1742 also blocks Toxoplasma gondii tachyzoite growth and profoundly disrupts parasite gene expression.

Physicochemical Properties

M.Wt	395.48
Formula	C21H21N3O3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-((4-([1,1'-Biphenyl]-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl)thio)-N-hydroxypentanamide

References

1. Di Pompo G, et al. J Med Chem. 2015 May 14;58(9):4073-9.

2. Mouveaux T, et al. Int J Antimicrob Agents. 2022 Mar;59(3):106526.

MC1742 (MC-1742)

Biological Activity

Physicochemical Properties

References

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

Get Quote

* Indicates a Required FieldYour information is safe with us.