MC2625 | HDAC inhibitor | Probechem Biochemicals

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Chemical Structure : MC2625

MC2625 (MC-2625)

Catalog No.: PC-27700Not For Human Use, Lab Use Only.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

MC2625 is a potent histone deacetylase (HDAC) inhibitor, shows selective HDAC3 and HDAC6 inhibition with IC50 of 80 nM and 11 nM respectively, also potently reactivate HIV from latency with EC50 of 350 nM.
MC2625 increases acetyl-H3 and acetyl-tubulin levels and inhibits cancer stem cells growth.
MC2625 induces growth arrest, apoptosis, and differentiation in sarcoma cancer stem cells (CSCs).

Physicochemical Properties

M.Wt	387.44
Formula	C23H21N3O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-3-(5-(2,3-diphenylpropanamido)pyridin-2-yl)-N-hydroxyacrylamide

References

1. Di Pompo G, et al. J Med Chem. 2015 May 14;58(9):4073-9.

2. Heffern EF, et al. J Virus Erad. 2019 Apr 1;5(2):84-91.

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MC2625 (MC-2625)

Biological Activity

Physicochemical Properties

References

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