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MC3343

Chemical Structure : MC3343

CAS No.: 1535187-91-7

MC3343 (MC-3343;MC 3343)

Catalog No.: PC-35290Not For Human Use, Lab Use Only.

MC3343 (MC-3343) is a novel potent, non-nucleoside DNA methyltransferase (DNMT) inhibitor with IC50 of 5.7 and 1.7 uM for DNMT1 and DNMT3a in cell-free assays, respectively.

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    Biological Activity

    MC3343 (MC-3343) is a novel potent, non-nucleoside DNA methyltransferase (DNMT) inhibitor with IC50 of 5.7 and 1.7 uM for DNMT1 and DNMT3a in cell-free assays, respectively.
    MC3343 displays increased potency against DNMT1 compared with RG-108 and SGI-1027.
    MC3343 efficiently inhibits OS cell proliferation and induces osteoblastic differentiation, induces dose- and time-dependent decreases in DNMT1, DNMT3a and DNMT3b protein levels in Saos-2 OS cells.
    MC3343 displays synergistic effects with doxorubicin and cisplatin in vivo, reduces patient-derived xenograft OS growth and induces differentiation.

    Physicochemical Properties

    M.Wt 461.529
    Formula C27H23N7O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    N-(3-(2-amino-6-methylpyrimidin-4-ylamino)phenyl)-3-(quinolin-4-ylamino)benzamide

    References

    1. Manara MC, et al. Mol Cancer Ther. 2018 Jun 29. pii: molcanther.0818.2017.

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