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MC4876

Chemical Structure : MC4876

CAS No.: 3144317-24-5

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MC4876 (MC-4876)

Catalog No.: PC-28569Not For Human Use, Lab Use Only.

MC4876 is a potent, selective NADPH oxidase 2 (NOX2) inhibitor with IC50 of 7.7 uM (hNOX2), shows much weaker acitivty against hNOX1 (71.2 uM), hNOX4 (81.2 uM) and hNOX5 (28 uM).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

MC4876 is a potent, selective NADPH oxidase 2 (NOX2) inhibitor with IC50 of 7.7 uM (hNOX2), shows much weaker acitivty against hNOX1 (71.2 uM), hNOX4 (81.2 uM) and hNOX5 (28 uM).

Physicochemical Properties

M.Wt 303.41
Formula C20H21N3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-phenyl-N-(piperidin-4-yl)quinolin-2-amine

References

1. Chiara Lambona, et al. J Med Chem. 2026 Oct 22;69(20):24557-24585.

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