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Chemical Structure : MCL0129 tetrahydrochloride
Catalog No.: PC-61571Not For Human Use, Lab Use Only.
MCL0129 is a selective, potent melanocortin-4 receptor (MC4R) antagonist with Ki of 7.9 nM, without affinity for MC1 and MC3.
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MCL0129 is a selective, potent melanocortin-4 receptor (MC4R) antagonist with Ki of 7.9 nM, without affinity for MC1 and MC3; attenuates the alpha-MSH-increased cAMP formation in COS-1 cells expressing the MC4, does not affect basal cAMP levels; exhibits anxiolytic- and antidepressant-like activities in various rodent models.
Depression
Discontinued
| M.Wt | 692.607 | |
| Formula | C34H51Cl4FN4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Chaki S, et al. J Pharmacol Exp Ther. 2003 Feb;304(2):818-26.
2. Shimazaki T, et al. Pharmacol Biochem Behav. 2005 Mar;80(3):395-400.
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