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Chemical Structure : MCP110
Catalog No.: PC-62206Not For Human Use, Lab Use Only.
MCP110 is a potent Ras/Raf-1 interaction inhibitor.
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MCP110 is a potent Ras/Raf-1 interaction inhibitor.
MCP110 inhibits Ras-induced Raf-1 activation in human embryonic kidney 293 cells, Raf-1 and MAPK1 activities in HT1080 fibrosarcoma cells, and EGF-induced Raf-1 activation in A549 lung carcinoma cells.
MCP110 inhibits anchorage-independent growth of A549 and PANC-1 cells harboring K-ras mutation.
MCP110 causes G1 enrichment of A549 cells with the decrease of cyclin D level.
MCP110 inhibits the growth of LXFA 629 lung and SW620 colon carcinoma cells in xenograft models.
| M.Wt | 508.662 | |
| Formula | C33H36N2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kato-Stankiewicz J, et al. Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14398-403.
2. Skobeleva N, et al. Mol Cancer Ther. 2007 Mar;6(3):898-906.
3. González-Pérez V, et al. J Mol Signal. 2010 Feb 23;5:2.
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