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Chemical Structure : MD102
Catalog No.: PC-21655Not For Human Use, Lab Use Only.
MD102 is a potent transglutaminase 2 (TGase 2; TG2) inhibitor with IC50 of 0.35 uM, shows p53 stabilization effect and anticancer activity at RCC cell lines.
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MD102 is a potent transglutaminase 2 (TGase 2; TG2) inhibitor with IC50 of 0.35 uM, shows p53 stabilization effect and anticancer activity at RCC cell lines.
MD102 exhibits p53 stabilization effect and anticancer effects in the ACHN and Caki-1 RCC cell lines with sulforhodamine B (SRB) GI50 values of 2.15 µM and 1.98 µM, respectively.
MD102 induced apoptosis and disturbance of the interaction between p53 and TG2 through regulating the p53/AKT/mTOR signaling.
MD102 (15 mpk, i.p., 50 mpk p.o.) inhibited ACHN xenograft growth in nude mice.
| M.Wt | 389.99 | |
| Formula | C13H4BrCl2FN2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kim GR, et al. Bioorg Chem. 2023 Dec 25;143:107061.
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