Catalog No.: PC-28586Not For Human Use, Lab Use Only.
MD2-IN-1 (Compound 20) is a selective small molecule inhibitor of Myeloid differentiation 2 (MD2) with anti-inflammatory properties, inhibits TLR4/MD2 complex, dose-dependent inhibits LPS-induced TNF-α and IL-6 release with IC50 of 4.27 and 2.06 uM in MPMs.
MD2-IN-1 (Compound 20) is a selective small molecule inhibitor of Myeloid differentiation 2 (MD2) with anti-inflammatory properties, inhibits TLR4/MD2 complex, dose-dependent inhibits LPS-induced TNF-α and IL-6 release with IC50 of 4.27 and 2.06 uM in MPMs. MD2-IN-1 exhibits recognizable binding to rhMD2 protein in a dose-dependent manner, with a KD value of 189 uM. MD2-IN-1 inhibits the LPS-induced overexpression of TNF-α and IL-6 in mouse peritoneal macrophages (MPMs). MD2-IN-1 has no binding affinity to rhTLR4 protein, does not affect the MD2-independent TLR2 pro-inflammatory pathway. MD2-IN-1 inhibits LPS-induced activation of NF-κB and MAPKs, and expression of inflammatory genes in MPMs. MD2-IN-1 reduced LPS-induced pulmonary edema in rats, decreases LPS-induced MPO activity in the lung tissue.
