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Chemical Structure : ME0328
CAS No.: 1445251-22-8
Catalog No.: PC-35508Not For Human Use, Lab Use Only.
ME0328 (ME-0328) is a potent, selective inhibitor of ADP-ribosyltransferase ARTD3/PARP3 with IC50 of 0.89 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $168 | In stock | |
| 100 mg | $458 | In stock | |
| 250 mg | $858 | In stock | |
| 1 g | Get quote |
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ME0328 (ME-0328) is a potent, selective inhibitor of ADP-ribosyltransferase ARTD3/PARP3 with IC50 of 0.89 uM; displays selectivity for PARP-3 over PARP-1, PARP-2 and other ARDT enzymes (IC50=6.3, 10.8 and >30 uM respectively); potentiates vinorelbine sensitization in breast cancer cell lines at the G2/M boundary, also potentiates vinorelbine-induced PARP3 inhibition, mitotic arrest, and apoptosis.
| M.Wt | 321.38 | |
| Formula | C19H19N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3,4-Dihydro-4-oxo-N-[(1S)-1-phenylethyl]-2-quinazolinepropanamide |
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1. Lindgren AE, et al. ACS Chem Biol. 2013 Aug 16;8(8):1698-703.
2. Sharif-Askari B, et al. Breast Cancer Res Treat. 2018 Jul 23. doi: 10.1007/s10549-018-4888-6.
3. Wang H, et al. Cancer Lett. 2017 Jan 28;385:137-143.
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