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Chemical Structure : MG-101
CAS No.: 110044-82-1
Catalog No.: PC-45577Not For Human Use, Lab Use Only.
A potent inhibitor of cysteine proteases including calpain I (Ki= 190 nM), calpain II (Ki= 220 nM), cathepsin B (Ki= 150 nM) and cathepsin L (Ki= 500 pM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $96 | In stock | |
| 50 mg | $320 | In stock | |
| 100 mg | $520 | In stock |
Bulk size, bulk discount!
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A potent inhibitor of cysteine proteases including calpain I (Ki= 190 nM), calpain II (Ki= 220 nM), cathepsin B (Ki= 150 nM) and cathepsin L (Ki= 500 pM); activates p53-dependent apoptosis in tumor cell lines; increases activated p53, p21 and caspase levels and promotes cell cycle arrest through inhibition of cyclin D degradation in vitro.
| M.Wt | 383.5255 | |
| Formula | C20H37N3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
L-Leucinamide, N-acetyl-L-leucyl-N-[(1S)-1-formylpentyl]- |
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1. Zhang L, et al. J Biol Chem. 1999 Mar 26;274(13):8966-72.
2. Inoue S,et al. J Biol Chem. 1991 Jul 15;266(20):13311-7.
3. Sherwood SW, et al. Proc Natl Acad Sci U S A. 1993 Apr 15;90(8):3353-7.
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