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MG-C-30

Chemical Structure : MG-C-30

CAS No.: 877164-43-7

MG-C-30

Catalog No.: PC-28379Not For Human Use, Lab Use Only.

MG-C-30 is a small molecule CD27 agonist with EC50 of 0.84 uM in 4-IBB and CD27 reporter cell assays, augments 4-IBB and CD27 signaling in vitro, potentiates the secretion of TNF-α and IFN-γ in PBMCs, activate natural killer cells, delays tumor growth in EG7-OVA tumor-bearing mice.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

MG-C-30 is a small molecule CD27 agonist with EC50 of 0.84 uM in 4-IBB and CD27 reporter cell assays, augments 4-IBB and CD27 signaling in vitro, potentiates the secretion of TNF-α and IFN-γ in PBMCs, activate natural killer cells, delays tumor growth in EG7-OVA tumor-bearing mice.

Physicochemical Properties

M.Wt 450.56
Formula C24H26N4O3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(1-(1H-Benzo[d]imidazol-2-yl)-2-methylpropyl)-2-(2-(3,4-dimethoxyphenyl)thiazol-4-yl)acetamide

References

1. Abdel-Rahman SA, et al. Sci Adv. 2024 Oct 18;10(42):eadq5540.

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