MG-T-19

Chemical Structure : MG-T-19

Catalog No.: PC-28380Not For Human Use, Lab Use Only.

MG-T-19 is a potent, small-molecule T-cell immunoglobulin and mucin domain-containing protein 3 (Tim-3, HAVCR2) inhibitor with MST KD of 0.26 uM.

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Biological Activity

MG-T-19 is a potent, small-molecule T-cell immunoglobulin and mucin domain-containing protein 3 (Tim-3, HAVCR2) inhibitor with MST KD of 0.26 uM.
MG-T-19 demonstrates significant inhibition of TIM-3 interactions with PtdSer, CEACAM1, and Gal-9 at 2.5 uM.
MG-T-19 increases tumor necrosis factor–α (TNF-α) and interferon-γ (IFN-γ) production of peripheral blood mononuclear cells (PBMCs).
MG-T-19 augments the capacity of PBMCs to impede the proliferation of Kasumi-1 cells (acute myelogenous leukemia cell line) in a coculture assay.

Physicochemical Properties

M.Wt	596.60
Formula	C18H8Br2ClF3N4O2S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-Bromo-5-(4-bromothiophen-2-yl)-N-(5-chloro-2-hydroxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide

References

1. Abdel-Rahman SA, et al. Sci Adv. 2024 Oct 18;10(42):eadq5540.

MG-T-19

Biological Activity

Physicochemical Properties

References

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