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Chemical Structure : MGL-3196
CAS No.: 920509-32-6
Catalog No.: PC-42920Not For Human Use, Lab Use Only.
MGL-3196 (VIA-3196, Resmetirom) is a potent and highly selective agonist of THR-β (Thyroid Hormone Receptor β) with EC50 of 0.21 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $198 | In stock | |
| 100 mg | $498 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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MGL-3196 (VIA-3196, Resmetirom) is a potent and highly selective agonist of THR-β (Thyroid Hormone Receptor β) with EC50 of 0.21 uM.
MGL-3196 shows 28-fold selectivity for THR-β over THR-α in a functional assay.
MGL-3196 exhibits an excellent safety profile and orally bioactive.
| M.Wt | 435.221 | |
| Formula | C17H12Cl2N6O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 31 mg/mL |
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| Chemical Name/SMILES |
1,2,4-Triazine-6-carbonitrile, 2-[3,5-dichloro-4-[[1,6-dihydro-5-(1-methylethyl)-6-oxo-3-pyridazinyl]oxy]phenyl]-2,3,4,5-tetrahydro-3,5-dioxo- |
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1. Kelly MJ, et al. J Med Chem. 2014 May 22;57(10):3912-23.
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