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Chemical Structure : MIM1
CAS No.: 509102-00-5
Catalog No.: PC-45041Not For Human Use, Lab Use Only.
A potent, selective small molecule Mcl-1 inhibitor that selectively targets the BH3-binding groove of Mcl-1.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $400 | In stock | |
| 50 mg | Get quote |
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A potent, selective small molecule Mcl-1 inhibitor that selectively targets the BH3-binding groove of Mcl-1; effectively competes with FITC-MCL-1 SAHBA and FITC-BID BH3 for MCL-1ΔNΔC binding with IC50 of 4.7 and 4.8 uM, respectively; shows no activity for Bcl-xL; induces caspase activation and leukemia cell death in the specific context of MCL-1 dependence.
| M.Wt | 347.4319 | |
| Formula | C17H21N3O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1,2,3-Benzenetriol, 4-[[[2-(cyclohexylimino)-4-methyl-3(2H)-thiazolyl]imino]methyl]- |
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1. Cohen NA, et al. Chem Biol. 2012 Sep 21;19(9):1175-86.
2. Habata S, et al. Int J Oncol. 2016 Jul;49(1):402-10.
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