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Chemical Structure : MINA53 inhibitor 10
Catalog No.: PC-72263Not For Human Use, Lab Use Only.
MINA53 inhibitor 10 is a first in class, potent, selective MINA53 inhibitor with IC50 of 1.5 uM, selective over NO66, KDM4-6 and other JmjC oxygenases.
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MINA53 inhibitor 10 is a first in class, potent, selective MINA53 inhibitor with IC50 of 1.5 uM, selective over NO66, KDM4-6 and other JmjC oxygenases.
MINA53 inhibitor 10 display no significant inhibitory effect against 20G Oxygenase panel (IC50>30 uM).
MINA53 inhibitor 10 binds to MINA53 by directly interacting with the iron cofactor.
MINA53 inhibitor 10 demonstrated antiproliferative effect in a panel of leukemia and lymphoma cell lines (HL60 IC50=14 uM), also sensitized cancer cells to conventional chemotherapy.
| M.Wt | 290.337 | |
| Formula | C14H14N2O3S | |
| Appearance | Solid | |
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1. Radosław P Nowak, et al. J Med Chem. 2021 Dec 9;64(23):17031-17050.
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