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Chemical Structure : MIND4-17
Catalog No.: PC-70279Not For Human Use, Lab Use Only.
MIND4-17 is an inducer of NRF2 that selectively activates NRF2 signaling with CD value (The concentration that doubles the specific activity) of 0.18 uM.
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MIND4-17 is an inducer of NRF2 that selectively activates NRF2 signaling with CD value (The concentration that doubles the specific activity) of 0.18 uM.
MIND4-17 covalently modifies a critical stress-sensor cysteine (C151) of the E3 ligase substrate adaptor protein KEAP1, arrests KEAP/NRF2 complex in the closed conformation in live cells.
MIND4-17 potently represses the release of the proinflammatory cytokine IL-6 in primary mouse HD and WT microglia and astrocytes.
| M.Wt | 405.432 | |
| Formula | C20H15N5O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Quinti L, et al. Proc Natl Acad Sci U S A. 2017 Jun 6;114(23):E4676-E4685.
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