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Chemical Structure : MK-0626
Catalog No.: PC-49042Not For Human Use, Lab Use Only.
MK-0626 (MK-626) is a potent, selective and orally active DPP-4 inhibitor (IC50=6.3 nM) with excellent selectivity.
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MK-0626 (MK-626) is a potent, selective and orally active DPP-4 inhibitor (IC50=6.3 nM) with excellent selectivity.
MK-0626 attenuates hepatic steatosis through enhancing AMPK activity, inhibiting hepatic lipogenic gene expression, enhancing triglyceride secretion from liver and increasing serum adiponectin levels in ob/ob mice.
MK-0626 significantly increased the mRNA expression of PPARα and microsomal triglyceride transfer protein but significantly reduced sterol regulatory element binding transcription factor-1c, fatty acid synthase and stearoyl-CoA desaturase-1.
| M.Wt | 442.47 | |
| Formula | C22H24F2N6O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Sangle GV, et al. Endocrinology. 2012 Feb;153(2):564-73.
2. Tatsuya Ohyama, et al. World J Gastroenterol. 2014 Nov 21;20(43):16227-35.
3. Edmondson SD. J Med Chem. 2006;49:3614–3627.
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