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Chemical Structure : MK-0812
Catalog No.: PC-45833Not For Human Use, Lab Use Only.
MK-0812 is a potent CCR2 specific antagonist that blocks MCP-1 mediated response with an IC50 of 3.2 nM.
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MK-0812 is a potent CCR2 specific antagonist that blocks MCP-1 mediated response with an IC50 of 3.2 nM.
MK-0812 inhibits 125I-MCP-1 binding on isolated monocytes with IC50 of 4.5 nM.
MK-0812 reduces macrophage accumulation in adipose tissue in ob/ob mice.
| M.Wt | 469.5403 | |
| Formula | C24H34F3N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Wisniewski T, et al. J Immunol Methods. 2010 Jan 31;352(1-2):101-10.
2. O'Brien PD, et al. Diabetes Obes Metab. 2017 Mar 23. doi: 10.1111/dom.12950.
3. Min SH, et al. Biochem Biophys Res Commun. 2010 Jan 1;391(1):1080-6.
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