Catalog No.: PC-26707Not For Human Use, Lab Use Only.
MK-1088 is a potent, selective dual adenosine A2A receptor (A2AR) and A2B receptor (A2BR) antagonist with Ki values of 0.31 nM and 5.3 nM for human A2AR and A2BR respectively.
MK-1088 is a potent, selective dual adenosine A2A receptor (A2AR) and A2B receptor (A2BR) antagonist with Ki values of 0.31 nM and 5.3 nM for human A2AR and A2BR respectively.
MK-1088 displays >100-fold selectivity over A1R and A3R versus A2AR.
MK-1088 exhibits high affinity for mouse A2AR and A2BR with Ki of 3.2 nM and 28 nM respectively.
MK-1088 shows potential to reverse adenosine-mediated suppression of tumor immune surveillance as either a single-agent treatment or in combination with other immunotherapy agents such as anti-PD-1/PD-L1 monoclonal antibodies.
