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Chemical Structure : MK-1421
Catalog No.: PC-61087Not For Human Use, Lab Use Only.
A potent, selective, orally active somatostatin receptor SSTR3 antagonist with binding Ki of 2.3 nM, >2,500-fold selectivity over SSTR1/2/4/5 (IC50>5 uM).
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A potent, selective, orally active somatostatin receptor SSTR3 antagonist with binding Ki of 2.3 nM, >2,500-fold selectivity over SSTR1/2/4/5 (IC50>5 uM); shows excellent efficacy in a mouse model of glucose excursion (oGTT) and demonstrates glucose-dependent release of insulin from relevant human tissue.
| M.Wt | 525.548 | |
| Formula | C27H24FN9O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Shah SK, et al. ACS Med Chem Lett. 2015 Mar 18;6(5):513-7.
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