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Chemical Structure : MK-2048
Catalog No.: PC-43481Not For Human Use, Lab Use Only.
MK-2048 is a potent inhibitor of HIV-1 integrase (IN) and IN mutant R263K with IC50 of 2.6 nM and 1.5 nM, respectively.
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MK-2048 is a potent inhibitor of HIV-1 integrase (IN) and IN mutant R263K with IC50 of 2.6 nM and 1.5 nM, respectively.
MK-2048 inhibits subtype B and subtype C integrase activities with IC50 of 75 nM and 80 nM, respectively.
MK-2048 inhibits S217H intasome with an IC50 of 900 nM, remains fully active against the N224H intasome with IC50 of 25 nM.
MK-2048 displays substantially lower dissociation rates compared with raltegravir, another integrase inhibitor.
| M.Wt | 461.87 | |
| Formula | C21H21ClFN5O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Quashie PK, et al. J Virol. 2012 Mar;86(5):2696-705.
2. Van Wesenbeeck L, et al. Antimicrob Agents Chemother. 2011 Jan;55(1):321-5.
3. Bar-Magen T, et al. J Virol. 2010 Sep;84(18):9210-6.
4. Marsden MD, et al. Antimicrob Agents Chemother. 2011 Aug;55(8):3696-702.
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