Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : MK-4256
Catalog No.: PC-61088Not For Human Use, Lab Use Only.
A potent, selective, orally active somatostatin receptor SSTR3 antagonist with binding Ki of 0.66 nM, >500-fold selectivity over SSTR1/2/4/5.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
A potent, selective, orally active somatostatin receptor SSTR3 antagonist with binding Ki of 0.66 nM, >500-fold selectivity over SSTR1/2/4/5; reduces glucose excursion in a dose-dependent fashion with maximal efficacy achieved at doses as low as 0.03 mg/kg po, with minimal hypoglycemia risk; preclinical tirals are discontinued due to dose-dependent QTc in conscious cardiovascular (CV) dog model.
| M.Wt | 494.534 | |
| Formula | C27H23FN8O | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. He S, et al. ACS Med Chem Lett. 2012 May 7;3(6):484-9.
2. He S, et al. ACS Med Chem Lett. 2014 Apr 21;5(7):748-53.
3. He S, et al. Bioorg Med Chem Lett. 2016 Mar 15;26(6):1529-1535.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
