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Chemical Structure : MK-7845
Catalog No.: PC-21803Not For Human Use, Lab Use Only.
MK-7845 is a potent, reversible covalent SARS-CoV-2 3CLPro inhibitor with IC50 of 8.7 nM, inhibits wild-type SARS-CoV-2 3CLPro in SARS-CoV-2 reporter replicon assay in A549 cells with IC50 of 15 nM.
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MK-7845 is a potent, reversible covalent SARS-CoV-2 3CLPro inhibitor with IC50 of 8.7 nM, inhibits wild-type SARS-CoV-2 3CLPro in SARS-CoV-2 reporter replicon assay in A549 cells with IC50 of 15 nM.
MK-7845 isplays 82-fold to >1000-fold selectivity agianst a panel of host-cell proteases.
MK-7845 otently inhibits P132H mutant 3CLPro present in the Omicron variant with IC50 of 15 nM.
MK-7845 hows similar activity against the parental WA1/2020, Delta, and Omicron strains of the virus with EC50 value of 215 nM-444 nM.
MK-7845 showed significant and dose-dependent reductions in viral load beginning at 250 mg/kg in mouse model of SARS-CoV-2 infection.
| M.Wt | 516.59 | |
| Formula | C24H38F2N4O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Valerie W Shurtleff, et al. J Med Chem. 2024 Feb 16. doi: 10.1021/acs.jmedchem.3c02248.
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