Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : MK-8033 hydrochloride
CAS No.: 1283000-43-0
Catalog No.: PC-43478Not For Human Use, Lab Use Only.
MK-8033 is a potent, specific, dual c-Met/Ron kinases inhibitor with IC50 of 1/7 nM, also potently inhibits oncogenic c-Met activation loop mutants Y1230C, Y1230H and Y1235D with IC50 of 0.6-1.2 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $285 | In stock | |
| 25 mg | $685 | In stock | |
| 100 mg | Get quote | ||
| 500 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
MK-8033 is a potent, specific, dual c-Met/Ron kinases inhibitor with IC50 of 1/7 nM, also potently inhibits oncogenic c-Met activation loop mutants Y1230C, Y1230H and Y1235D with IC50 of 0.6-1.2 nM; MK-8033 is >100-fold selective relative to Ron and c-Met inhibition against a panel of 221 kinases; potently and selectively inhibits growth in c-Met amplified cell lines (GTL-16 proliferation IC50 =582 nM), causes full inhibition of tumor growth in c-Met amplified (GTL-16) subcutaneous tumor xenograft model; synergizes with carboplatin plus paclitaxel to inhibit ovarian cancer cell growth.
Solid Tumors
Phase 1 Clinical
| M.Wt | ||
| Formula | C25H22ClN5O3S | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
5H-Benzo[4,5]cyclohepta[1,2-b]pyridine-7-methanesulfonamide, 3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-N-(2-pyridinylmethyl)-, hydrochloride (1:1) |
|
1. Northrup AB, et al. J Med Chem. 2013 Mar 28;56(6):2294-310.
2. Bhardwaj V, et al. J Thorac Oncol. 2012 Aug;7(8):1211-7.
3. Marchion DC, et al. Oncol Rep. 2013 May;29(5):2011-8.
4. Keedy VL, et al. Invest New Drugs. 2018 Jan 29. doi: 10.1007/s10637-018-0567-z.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
