Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : MK-8245 trifluoroacetate
CAS No.: 1415559-41-9
Catalog No.: PC-43378Not For Human Use, Lab Use Only.
MK-8245 trifluoroacetate is a potent, selective liver-targeted stearoyl-CoA desaturase (SCD) inhibitor with IC50 of 3, 3 and 1 nM for rat, mouse and human SCD1 enzyme, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $125 | In stock | |
| 25 mg | $285 | In stock | |
| 100 mg | $895 | In stock | |
| 500 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
MK-8245 trifluoroacetate is a potent, selective liver-targeted stearoyl-CoA desaturase (SCD) inhibitor with IC50 of 3, 3 and 1 nM for rat, mouse and human SCD1 enzyme, respectively; displays highly selective over the Δ-5 and Δ-6 desaturases (IC50>100 uM); has IC50 values of 68 nM and 1066 nM in Hum HepG2 and rat hepatocyte assays, demonstrates HepG2/hepatocyte ratio of 16:1; exhibits preclinical antidiabetic and antidyslipidemic efficacy in vivo, demonstrats maximal liver SCD inhibition while sparing inhibition in the skin and eye tissues associated with adverse events.
Diabetes
Phase 1 Discontinued
| M.Wt | 581.2725 | |
| Formula | C19H17BrF4N6O6 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
2H-Tetrazole-2-acetic acid, 5-[3-[4-(2-bromo-5-fluorophenoxy)-1-piperidinyl]-5-isoxazolyl]-, 2,2,2-trifluoroacetate (1:1) |
|
1. Oballa RM, et al. J Med Chem. 2011 Jul 28;54(14):5082-96.
2. Landry F, et al. J Lipid Res. 2011 Aug;52(8):1494-9.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
