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Chemical Structure : MK-8617
Catalog No.: PC-60308Not For Human Use, Lab Use Only.
A potent, orally active pan-inhibitor of HIF prolyl hydroxylase (HIF-PHD) with IC50 of 1.0,1.0, and 14 nM for HIF-PHD1, 2, and 3, respectively.
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A potent, orally active pan-inhibitor of HIF prolyl hydroxylase (HIF-PHD) with IC50 of 1.0,1.0, and 14 nM for HIF-PHD1, 2, and 3, respectively; shows no significant inhibition on the cytochrome p450 enzymes; exhibits good oral bioavailability, causes increases in circulating reticulocytes in mice and has potential for treatment of anemia.
| M.Wt | 443.45 | |
| Formula | C24H21N5O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Debenham JS, et al. J Med Chem. 2016 Dec 22;59(24):11039-11049.
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