Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : MK-8768
Catalog No.: PC-21049Not For Human Use, Lab Use Only.
MK-8768 (MK8768) is a potent, selective mGluR2 negative allosteric modulator (NAM) with IC50 of 9.6 nM, shows no activity against mGluR 1,3,4,5,6,8.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
MK-8768 (MK8768) is a potent, selective mGluR2 negative allosteric modulator (NAM) with IC50 of 9.6 nM, shows no activity against mGluR 1,3,4,5,6,8.
MK-8768 demonstrates an excellent overall selectivity profile with weak to no activity on the hERG, IKs, and Nav1.5 ion channels and no confirmed activities < 10 μM in a Panlabs screen of >120 off-targets.
MK-8768 exhibits good oral pharmacokinetics and demonstrated efficacy in a rhesus monkey model of executive function and attention.
| M.Wt | 433.44 | |
| Formula | C21H22F3N5O2 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Michael T Rudd, et al. ACS Med Chem Lett. 2023 Jul 12;14(8):1088-1094.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
