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MK2 inhibitor III

Chemical Structure : MK2 inhibitor III

CAS No.: 1186648-22-5

MK2 inhibitor III (MK2-IN-3)

Catalog No.: PC-70147Not For Human Use, Lab Use Only.

MK2 inhibitor III (MK2-IN-3) is a potent, cell-permeable inhibitor of MAPKAPK2 (MK2) with IC50 of 8.5 nM.

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Biological Activity

MK2 inhibitor III (MK2-IN-3) is a  potent, cell-permeable inhibitor of MAPKAPK2 (MK2) with IC50 of 8.5 nM.
MK2 inhibitor III (MK2-IN-3) less potently blocks MK3 and MK5 (IC50s=210 and 81 nM, respectively and is weak or inactive against several other kinases, including P38 MAPKs.
MK2 inhibitor III (MK2-IN-3) prevents LPS-induced synthesis of TNF-α in human monocyte-like U937 cells with IC50 of 4.4 uM.

Physicochemical Properties

M.Wt 358.4
Formula C21H16N4O • H2O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-(2-(quinolin-3-yl)pyridin-4-yl)-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one hydrate

References

1. Anderson DR, et al. J Med Chem. 2007 May 31;50(11):2647-54.

2. Gurgis F, et al. Cell Death Discov. 2015 Sep 7;1:15028.

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