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Chemical Structure : MKT-077
CAS No.: 147366-41-4
Catalog No.: PC-62565Not For Human Use, Lab Use Only.
MKT-077 (FJ-776) is a highly water-soluble (>200 mg/ml) rhodacyanine dye that exhibits significant antitumor activity, binds to Hsp70 family member, mortalin (mot-2), and abrogates its interactions with p53.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $158 | In stock | |
| 25 mg | $278 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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MKT-077 (FJ-776) is a highly water-soluble (>200 mg/ml) rhodacyanine dye that exhibits significant antitumor activity, binds to Hsp70 family member, mortalin (mot-2), and abrogates its interactions with p53.
MKT-077 induces release of wild-type p53 from cytoplasmically sequestered p53-mot-2 complexes and rescued its transcriptional activation function.
MKT-077 also is a potent telomerase inhibitor with IC50 of 5 uM.
| M.Wt | 432 | |
| Formula | C21H22ClN3OS2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Pyridinium, 1-ethyl-2-[[3-ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-4-oxo-2-thiazolidinylidene]methyl]-, chloride (9CI) |
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1. Koya K, et al. Cancer Res. 1996 Feb 1;56(3):538-43.
2. Wadhwa R, et al. Cancer Res. 2000 Dec 15;60(24):6818-21.
3. Naasani I, et al. Cancer Res. 1999 Aug 15;59(16):4004-11.
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