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Chemical Structure : ML-109
Catalog No.: PC-35977Not For Human Use, Lab Use Only.
ML-109 (ML109, CID-25246343) is the first selective and orally available small-molecule TSHR agonist with EC50 of 40 nM.
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ML-109 (ML109, CID-25246343) is the first selective and orally available small-molecule TSHR agonist with EC50 of 40 nM; ML109 is highly selective for human TSHR over other glycoprotein hormone receptors, such as LHCGR and FSHR (EC50>100 uM), and interacts with the receptor’s serpentine domain; increases mRNA levels for thyroglobulin, thyroperoxidase, sodium iodide symporter, and deiodinase type 2, as well as deiodinase type2 enzyme activity in primary cultures of human thyrocytes; stimulated thyroid function in mice.
| M.Wt | 523.589 | |
| Formula | C31H29N3O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Neumann S, et al. Proc Natl Acad Sci U S A. 2009 Jul 28;106(30):12471-6.
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