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Chemical Structure : ML-SA1
CAS No.: 332382-54-4
Catalog No.: PC-73025Not For Human Use, Lab Use Only.
ML-SA1 (Mucolipin-specific synthetic agonist 1) is a potent synthetic agonist for TRPML1.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $148 | In stock | |
| 50 mg | $238 | In stock | |
| 100 mg | $398 | In stock | |
| 500 mg | $698 | In stock | |
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ML-SA1 (Mucolipin-specific synthetic agonist 1) is a potent synthetic agonist for TRPML1.
ML-SA1 induces significant [Ca2+]cyt increases in HEK293 cells stably- or transiently-expressing ML1-4A.
ML-SA1 targets all three TRPMLs, the expression levels of TRPML2 and TRPML3 are very low, and TRPML1 is the predominant lysosomal TRPML channel.
ML-SA1 induces TRPML1-mediated Ca2+ release from lysosomes.
ML-SA1 and TRPML1 overexpression rescue the trafficking defects and reduce cholesterol accumulation in NPC cells.
| M.Wt | 362.429 | |
| Formula | C22H22N2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-[2-(3,4-Dihydro-2,2,4-trimethyl-1(2H)-quinolinyl)-2-oxoethyl]-1H-isoindole-1,3(2H)-dione |
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1. Dongbiao Shen, et al. Nat Commun. 2012 Mar 13;3:731.
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