Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : ML-SA5
CAS No.: 2418670-70-7
Catalog No.: PC-72043Not For Human Use, Lab Use Only.
ML-SA5 (Mucolipin 1 agonist ML-SA5) is a potent, small molecule agonist of transient receptor potential mucolipin 1 (TRPML1/MCOLN1/ML1), dose-dependently activated whole-endolysosomal ML1 currents in DMD myoblasts with EC50 of 285±144 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $178 | In stock | |
| 25 mg | $288 | In stock | |
| 50 mg | $458 | In stock | |
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
ML-SA5 (Mucolipin 1 agonist ML-SA5) is a potent, small molecule agonist of transient receptor potential mucolipin 1 (TRPML1/MCOLN1/ML1), dose-dependently activated whole-endolysosomal ML1 currents in DMD myoblasts with EC50 of 285±144 nM.
ML-SA5–induced lysosomal Ca2+ release, measured with GCaMP3 imaging, in primary myotubes isolated from ML1MCK mice.
ML-SA5 ML1 agonist ML-SA5 ameliorate muscular dystrophies, facilitates sarcolemma repair to reduce muscle damage, activates TFEB to correct lysosomal insufficiency in mdx mice.
| M.Wt | 457.988 | |
| Formula | C19H24ClN3O4S2 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
1,4-Benzenedisulfonamide, N4-[3-chloro-2-(1-piperidinyl)phenyl]-N1,N1-dimethyl- |
|
1. Lu Yu, et al. Sci Adv. 2020 Feb 7;6(6):eaaz2736.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
