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Chemical Structure : ML116
CAS No.: 744270-00-6
Catalog No.: PC-60659Not For Human Use, Lab Use Only.
ML116 is a selective STAT3 inhibitor with IC50 of 4.2 uM, does not inhibit STAT1, STAT5, or NFkB signaling pathways (IC50>50 uM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $278 | In stock | |
| 10 mg | $428 | In stock | |
| 25 mg | $728 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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ML116 is a selective STAT3 inhibitor with IC50 of 4.2 uM, does not inhibit STAT1, STAT5, or NFkB signaling pathways (IC50>50 uM).
ML116 inhibits transcription of the STAT3-regulated gene BCL3, slectively induces loss of viability of breast cancer cell lines such as MDA-MB-468 cells.
| M.Wt | 309.431 | |
| Formula | C18H19N3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-benzyl-1-{thieno[2,3-d]pyrimidin-4-yl}piperidine |
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1. Assi HH, et al. J Pharmacol Exp Ther. 2014 Jun;349(3):458-69.
2. Madoux F, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].
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