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Chemical Structure : ML2-SA1
Catalog No.: PC-72671Not For Human Use, Lab Use Only.
ML2-SA1 is a potent, selective and efficacious activator (agonist) of TRPML2 with EC50 of 1.24 uM and 2.38 uM for human and mouse TRPML2, respectively.
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ML2-SA1 is a potent, selective and efficacious activator (agonist) of TRPML2 with EC50 of 1.24 uM and 2.38 uM for human and mouse TRPML2, respectively.
ML2-SA1 displays high selectivity for TRPML2 and no significant activity at the related TRPML1 and TRPML3 channels.
ML2-SA1 directly stimulates release of the chemokine CCL2 from macrophages, also stimulates macrophage migration, thus mimicking CCL2 function.
| M.Wt | 282.2 | |
| Formula | C14H13Cl2NO | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Plesch E, et al. Elife. 2018 Nov 27;7:e39720.
2. Santoni G, et al. Int J Mol Sci. 2022 Jan 8;23(2):688.
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