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Chemical Structure : ML204
CAS No.: 5465-86-1
Catalog No.: PC-43288Not For Human Use, Lab Use Only.
ML204 is a potent, selective antagonist of TRPC4 and TRPC5 channels, inhibits TRPC4β-mediated intracellular Ca(2+) rise with IC50 of 0.96 uM, exhibits 19-fold selectivity against TRPC6 channel.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $98 | In stock | |
| 50 mg | $158 | In stock | |
| 100 mg | $248 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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ML204 is a potent, selective antagonist of TRPC4 and TRPC5 channels, inhibits TRPC4β-mediated intracellular Ca(2+) rise with IC50 of 0.96 uM, exhibits 19-fold selectivity against TRPC6 channel.
ML204 blocks TRPC4β currents activated through either μ-opioid receptor stimulation (50 nm DAMGO, IC50=3.55 uM) or intracellular dialysis of GTPγS (IC50=2.85 uM).
ML204 shows no appreciable block by 10-20 uM for TRPV1, TRPV3, TRPA1, and TRPM8, as well as KCNQ2 and Nav Channels.
ML204 also inhibits TRPC5 channel currents activated through co-stimulation of Gi/o and Gq/11 signaling by μ-opioid and M3-like muscarinic receptors.
| M.Wt | 226.3168 | |
| Formula | C15H18N2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 37 mg/mL |
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| Chemical Name/SMILES |
Quinoline, 4-methyl-2-(1-piperidinyl)- |
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1. Miller M, et al. J Biol Chem. 2011 Sep 23;286(38):33436-46.
2. Zhang L, et al. Neuropharmacology. 2013 Sep;72:106-15.
3. Carson C, et al. PLoS One. 2015 Jun 22;10(6):e0127498.
4. Alawi KM, et al. Ann Rheum Dis. 2017 Jan;76(1):252-260.
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