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Chemical Structure : ML224
CAS No.: 1338824-21-7
Catalog No.: PC-43013Not For Human Use, Lab Use Only.
ML224 (NCGC00242364, ANTAG3) is a potent selective thyroid stimulating hormone receptor (TSHR) inverse agonist, selectively inhibits TSH-stimulated cAMP production with IC50 of 2.3 uM.
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|---|---|---|---|
| 5 mg | $198 | In stock | |
| 10 mg | $298 | In stock | |
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| 100 mg | Get quote |
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ML224 (NCGC00242364, ANTAG3) is a potent selective thyroid stimulating hormone receptor (TSHR) inverse agonist, selectively inhibits TSH-stimulated cAMP production with IC50 of 2.3 uM.
ML224 (NCGC00242364, ANTAG3) inhibits TSHR basal activity with IC50 of 6.0 uM, displays >20-fold selectivity over LHR and FSHR.
ML224 (NCGC00242364, ANTAG3) inhibits stimulation of thyroid function in female mice.
ML224 (NCGC00242364, ANTAG3) is a potential lead for development of drugs to treat TSHR-mediated hyperthyroidism caused by constitutively activating mutations or stimulating auto-antibodies associated with Graves’ disease.
| M.Wt | 525.5949 | |
| Formula | C31H31N3O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Acetamide, N-[4-[[5-[3-(2-furanylmethyl)-1,2,3,4-tetrahydro-4-oxo-2-quinazolinyl]-2-methoxyphenyl]methoxy]-3,5-dimethylphenyl]- |
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1. Neumann S, et al. Endocrinology. 2014 Jan;155(1):310-4.
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