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Chemical Structure : ML236
Catalog No.: PC-38805Not For Human Use, Lab Use Only.
ML236 is a potent, B-cell specific NF-κB inhibitor with IC50 of 35 nM, selective for the NF-κB pathway induced by PKC activators (phorbol myristic acetate/ionomycin) and selective for B-cells.
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ML236 is a potent, B-cell specific NF-κB inhibitor with IC50 of 35 nM, selective for the NF-κB pathway induced by PKC activators (phorbol myristic acetate/ionomycin) and selective for B-cells.
ML236 displays >400-fold selective over both the NF-κB activation in T-cells and against TNFα-mediated NF-κB activation.
| M.Wt | 287.363 | |
| Formula | C16H21N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Pu J, et al. In: Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010–.
2. Lee HH, et al. Cancers (Basel). 2019 Dec 30;12(1):98.
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