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Chemical Structure : ML254
CAS No.: 1428630-86-7
Catalog No.: PC-38454Not For Human Use, Lab Use Only.
ML254 (VU0430644) is a potent, selective metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulator with EC50 of 9.3 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $188 | In stock | |
| 25 mg | $348 | In stock | |
| 50 mg | $658 | In stock | |
| 100 mg | Get quote | ||
| 1 g | Get quote |
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ML254 (VU0430644) is a potent, selective metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulator with EC50 of 9.3 nM.
ML254 is highly selective for mGlu5 versus other mGlu receptors, as well as a panel of 68 GPCRs, ion channels and transporters.
ML254 demonstrates a robust reversal of amphetamine induced hyperlocomotion at a single dose in an in vivo model of psychosis.
| M.Wt | 310.32 | |
| Formula | C18H15FN2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
5-[2-(3-Fluorophenyl)ethynyl]-N-(3-methyl-3-oxetanyl)-2-pyridinecarboxamide |
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1. Turlington M, et al. J Med Chem. 2013 Oct 24;56(20):7976-96.
2. Zhou Y, et al. Bethesda (MD): National Center for Biotechnology Information (US); 2010–.
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