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Chemical Structure : ML309
Catalog No.: PC-62686Not For Human Use, Lab Use Only.
ML309 is a potent, selective mutant IDH1 R132H inhibitor with IC50 of 96 nM, displays >380-fold selectivity over wt IDH1.
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ML309 is a potent, selective mutant IDH1 R132H inhibitor with IC50 of 96 nM, displays >380-fold selectivity over wt IDH1.
ML309 reduces cell-based production of 2-HG in a U87MG mutant glioblastoma cell line (IC50=509 nM) and show no cytotoxicity.
ML309 has good in vitro ADME and in vivo PK profile.
| M.Wt | 484.575 | |
| Formula | C29H29FN4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Merk A, et al. Cell. 2016 Jun 16;165(7):1698-707.
2. Davis M, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].
3. Davis MI, et al. J Biol Chem. 2014 May 16;289(20):13717-25.
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