ML346 | HSP70 activator | Probechem Biochemicals

Chemical Structure : ML346

CAS No.: 100872-83-1

ML346 (ML 346)

Catalog No.: PC-45512Not For Human Use, Lab Use Only.

ML346 is a small molecule activator of HSP70 with EC50 of 4.6 uM, induces HSF-1-dependent chaperone expression.

Packing	Price	Stock
5 mg	$88	In stock
10 mg	$128	In stock
25 mg	$218	In stock
50 mg	$358	In stock
100 mg		Get quote

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Biological Activity

ML346 is a small molecule activator of HSP70 with EC50 of 4.6 uM, induces HSF-1-dependent chaperone expression.
ML346 restores protein folding in conformational disease models, which are mediated by novel mechanisms involving FOXO, HSF-1, and Nfr-2.

Physicochemical Properties

M.Wt	272.2561
Formula	C14H12N2O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	DMSO: ≥ 29 mg/mL
Chemical Name/SMILES	2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-[3-(4-methoxyphenyl)-2-propen-1-ylidene]-

References

1. Calamini B, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].

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ML346 (ML 346)

Biological Activity

Physicochemical Properties

References

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