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Chemical Structure : ML395
Catalog No.: PC-62138Not For Human Use, Lab Use Only.
ML395 is a potent, selective, allosteric phospholipase D2 (PLD2) inhibitor with cellular IC50 of 360 nM, shows >80-fold selectivity over PLD1 (IC50>30 uM).
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ML395 (VU0468809) is a potent, selective, allosteric phospholipase D2 (PLD2) inhibitor with cellular IC50 of 360 nM, shows >80-fold selectivity over PLD1 (IC50>30 uM).
ML395 (VU0468809) displays exceptional solubility, stability and PK; an improvement over the first generation PLD2 selective inhibitor, ML298.
ML395 (VU0468809) is an useful tool to probe selective PLD2 function in vitro and in vivo, demonstrates broad-spectrum antiviral activity in cellular assays against a range of influenza strains (H1, H3, H5 and H7).
| M.Wt | 443.551 | |
| Formula | C26H29N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. O'Reilly MC, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].
2. O'Reilly MC, et al. ChemMedChem. 2014 Dec;9(12):2633-7.
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