Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : ML404
Catalog No.: PC-62135Not For Human Use, Lab Use Only.
ML404 is a small molecule inhibitor of mtPTP, inhibits mitochondrial swelling with EC50 of 4.9 nM, shows no effect on mitochondrial coupling at >100 uM.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
ML404 is a small molecule inhibitor of mtPTP, inhibits mitochondrial swelling with EC50 of 4.9 nM, shows no effect on mitochondrial coupling at >100 uM; increases the calcium retention capacity (CRC) of mitochondria (a measure of mtPTP inhibition) 14.8-fold at 12.5 uM, a concentration that does not affect mitochondrial respiration at which the compound appears non-toxic; 2.3-fold more effective inhibitor than GNX-865.
| M.Wt | 328.75 | |
| Formula | C17H13ClN2O3 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Sileikyte J, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
