ML406 | Mtb bioA inhibitor | Probechem Biochemicals

Chemical Structure : ML406

CAS No.: 774589-47-8

ML406 (ML-406)

Catalog No.: PC-62126Not For Human Use, Lab Use Only.

ML406 is a small molecule Mtb bioA (DAPA synthase) enzyme inhibitor (IC50=30 nM) that shows anti-tubercular activity, dispalys >100-fold selectivity over bioD.

Packing	Price	Stock
10 mg	$88	In stock
25 mg	$148	In stock
50 mg	$248	In stock
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Biological Activity

ML406 is a small molecule Mtb bioA (DAPA synthase) enzyme inhibitor (IC50=30 nM) that shows anti-tubercular activity, dispalys >100-fold selectivity over bioD.
ML406 exhibits WT M. tb (H37Rv) growth inhibition without biotin with an IC50 of 3.2 uM.

Physicochemical Properties

M.Wt	352.39
Formula	C20H20N2O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(4-(4-(Benzo[d][1,3]dioxole-5-carbonyl)piperazin-1-yl)phenyl)ethanone

References

1. Casalena D, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].

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ML406 (ML-406)

Biological Activity

Physicochemical Properties

References

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