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Chemical Structure : MLN3126
Catalog No.: PC-35220Not For Human Use, Lab Use Only.
MLN3126 (MLN 3126, MLN-3126) is a potent, selective, orally available CCR9 antagonist with IC50 of 6.3 nM (CCL25-induced calcium mobilization).
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MLN3126 (MLN 3126, MLN-3126) is a potent, selective, orally available CCR9 antagonist with IC50 of 6.3 nM (CCL25-induced calcium mobilization).
MLN3126 shows no significant antagonistic activity for other 12 chemokine receptors (CCR1, -2b, -4, -6, -7, -8, -10,CX3CR1, CXCR1, -2, -3 and -4) at 10 uM.
MLN3126 dose dependently inhibits CCL25-induced chemotaxis of mouse thymocytes (IC90=1.8 uM).
MLN3126 ameliorates inflammation in a T cell mediated mouse colitis model.
| M.Wt | 446.902 | |
| Formula | C21H19ClN2O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Igaki K, et al. Int Immunopharmacol. 2018 Jul;60:160-169.
2. Narita N, et al. Drug Metab Dispos. 2018 Mar;46(3):204-213.
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