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MLN3126

Chemical Structure : MLN3126

CAS No.: 628300-71-0

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MLN3126 (MLN 3126, MLN-3126)

Catalog No.: PC-35220Not For Human Use, Lab Use Only.

MLN3126 (MLN 3126, MLN-3126) is a potent, selective, orally available CCR9 antagonist with IC50 of 6.3 nM (CCL25-induced calcium mobilization).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

MLN3126 (MLN 3126, MLN-3126) is a potent, selective, orally available CCR9 antagonist with IC50 of 6.3 nM (CCL25-induced calcium mobilization).
MLN3126 shows no significant antagonistic activity for other 12 chemokine receptors (CCR1, -2b, -4, -6, -7, -8, -10,CX3CR1, CXCR1, -2, -3 and -4) at 10 uM.
MLN3126 dose dependently inhibits CCL25-induced chemotaxis of mouse thymocytes (IC90=1.8 uM).
MLN3126 ameliorates inflammation in a T cell mediated mouse colitis model.

Physicochemical Properties

M.Wt 446.902
Formula C21H19ClN2O5S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-{4-chloro-2-[(1-oxidopyridin-4-yl)carbonyl]phenyl}-4-(propan-2-yloxy)benzenesulfonamide

References

1. Igaki K, et al. Int Immunopharmacol. 2018 Jul;60:160-169.

2. Narita N, et al. Drug Metab Dispos. 2018 Mar;46(3):204-213.

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