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Chemical Structure : MLN 3897
Catalog No.: PC-61966Not For Human Use, Lab Use Only.
MLN 3897 is a potent, specific and orally active antagonist of CCR1 with IC50 of 0.8 nM in competition binding assays, 500-fold selectivity over CCR5.
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MLN 3897 is a potent, specific and orally active antagonist of CCR1 with IC50 of 0.8 nM in competition binding assays, 500-fold selectivity over CCR5.
MLN 3897 inhibits osteoclastogenesis and OC activity by impairing multinucleation and by down-regulation of c-fos signaling, inhibits osteoclastogenesis and OC activity by impairing multinucleation and by down-regulation of c-Fos signaling; demonstrates potential for the treatment of multiple sclerosis and rheumatoid arthritis.
| M.Wt | 535.125 | |
| Formula | C32H39ClN2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Gilchrist A, et al. Br J Pharmacol. 2014 Nov;171(22):5127-38.
2. Vallet S, et al. Blood. 2007 Nov 15;110(10):3744-52.
3. Lu C, et al. J Pharmacol Exp Ther. 2010 Feb;332(2):562-8.
4. Vergunst CE, et al. Arthritis Rheum. 2009 Dec;60(12):3572-81.
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