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MLT-231

Chemical Structure : MLT-231

CAS No.: 2682102-10-7

MLT-231 (MLT231)

Catalog No.: PC-49480Not For Human Use, Lab Use Only.

MLT-231 (MLT231) is a highly potent, selective, allosteric MALT1 inhibitor with biochemical IC50 of 9 nM, inhibits MALT1 cleavage of the BCL10 substrate with IC50 of 0.16 uM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

MLT-231 (MLT231) is a highly potent, selective, allosteric MALT1 inhibitor with biochemical IC50 of 9 nM, inhibits MALT1 cleavage of the BCL10 substrate with IC50 of 0.16 uM.
MLT-231 exhibited high MALT1 selectivity over other proteases.
MLT-231 inhibited cellular proliferation (low micromolar range) and cleavage of MALT1 substrates in ABC-DLBCL.
MLT-231 (100 mg/kg) dose-dependently reduced the anti-DNP IgM and IgG responses induced by 2,4-dinitrophenol (DNP) in mice, blocked T cell-dependent B cell responses.
MLT-231 (100 mg/kg, oral bid schedule for 2 weeks) exhibited antitumor efficacy in OCI-Ly10 ABC-DLBCL type xenograft models.

Physicochemical Properties

M.Wt 469.853
Formula C19H19ClF3N7O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1-(2-Chloro-7-((3S,5S)-3,5-dimethylmorpholino)pyrazolo[1,5-a]pyrimidin-6-yl)-3-(2-(trifluoromethyl)pyridin-4-yl)urea

References

1. Carole Pissot Soldermann, et al. J Med Chem. 2020 Dec 10;63(23):14576-14593.

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