You are here:Home-Chemical Inhibitors & Agonists-Autophagy-LRRK2-MLi-2
MLi-2

Chemical Structure : MLi-2

CAS No.: 1627091-47-7

MLi-2 (MLi2;Mli 2)

Catalog No.: PC-42142Not For Human Use, Lab Use Only.

MLi2 is a potent, selective, orally available and brain-penetrant LRRK2 inhibitor with kinase IC50 of 0.76 nM, cellular IC50 of 1.4 nM (dephosphorylation of LRRK2 pSer935 LRRK2).

Packing Price Stock Quantity
10 mg $188 In stock
25 mg $318 In stock
50 mg $528 In stock
100 mg $898 In stock
200 mg Get quote
1 g Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

MLi2 is a potent, selective, orally available and brain-penetrant LRRK2 inhibitor with kinase IC50 of 0.76 nM, cellular IC50 of 1.4 nM (dephosphorylation of LRRK2 pSer935 LRRK2).
MLi2 displays >295-fold selectivity for over 300 kinases in addition to a diverse panel of receptors and ion channels.
MLi2 signficantly reduces the ratio of phosphorylated Ser935 LRRK2 (pS935) to total LRRK2 in the mouse cortex, consistent with enlarged type II pneumocytes.

Physicochemical Properties

M.Wt 379.4555
Formula C21H25N5O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 26 mg/mL

Chemical Name/SMILES

1H-Indazole, 3-[6-[(2R,6S)-2,6-dimethyl-4-morpholinyl]-4-pyrimidinyl]-5-[(1-methylcyclopropyl)oxy]-, rel-

References

1. Scott JD, et al. J Med Chem. 2017 Apr 13;60(7):2983-2992.

2. Fell MJ, et al. J Pharmacol Exp Ther. 2015 Dec;355(3):397-409.

3. Volpicelli-Daley LA, et al. J Neurosci. 2016 Jul 13;36(28):7415-27.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: