Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : MMP408
CAS No.: 1258003-93-8
Catalog No.: PC-20540Not For Human Use, Lab Use Only.
MMP408 (MMP 408) is a potent, selective matrix metalloprotease 12 (MMP-12) inhibitor with IC50 of 2.0 nM (human MMP-12), 60-fold selectivity over MMP-13.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
MMP408 (MMP 408) is a potent, selective matrix metalloprotease 12 (MMP-12) inhibitor with IC50 of 2.0 nM (human MMP-12), 60-fold selectivity over MMP-13.
MMP408 has lower potency in rodent MMP-12 (80- and 160-fold less active for mouse and rat, respectively).
MMP408 displays a good selectivity profile (>500-fold) over other human MMPs (MMP-1, 3, 7, 9, 14, and TACE, Agg-1, Agg-2).
MMP408 (5 mg/kg, b.i.d. po) attenuates pulmonary inflammation in rhMMP-12 induced lung inflammation model.
| M.Wt | 420.44 | |
| Formula | C19H20N2O7S | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
CC(C)[C@H](NS(=O)(C1=CC=C2C(OC3=CC=C(NC(OC)=O)C=C23)=C1)=O)C(O)=O |
|
1. Li W, et al. J Med Chem. 2009 Apr 9;52(7):1799-802.
2. Zang N, et al. J Virol. 2015 Dec 16;90(5):2536-43.
3. Makino A, et al. iScience. 2021 Oct 2;24(10):103201.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
