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Chemical Structure : MMV019721
Catalog No.: PC-72539Not For Human Use, Lab Use Only.
MMV019721 (MMV019721) is an antiplasmodial drug-like compound tageting Plasmodium falciparum acetyl-coenzyme A synthetase (PfAcAS), directly and selectively inhibit PfAcAS activity in vitro with IC50 of 73 nM.
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MMV019721 (MMV019721) is an antiplasmodial drug-like compound tageting Plasmodium falciparum acetyl-coenzyme A synthetase (PfAcAS), directly and selectively inhibit PfAcAS activity in vitro with IC50 of 73 nM.
MMV019721 directly inhibits PfAcAS by preventing CoA binding.
MMV019721 has activity against blood-stage parasites in vitro (P. falciparum 3D7, EC50=460 nM) and against liver-stage P. berghei parasites (Pbluc EC50=2,000 nM).
MMV019721 directly and selectively inhibits PfAcAS activity in vitro.
| M.Wt | 437.957 | |
| Formula | C19H20ClN3O3S2 | |
| Appearance | Solid | |
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1. Robert L Summers, et al. Cell Chem Biol. 2022 Feb 17;29(2):191-201.e8.
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