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Chemical Structure : MMV1091186
Catalog No.: PC-20099Not For Human Use, Lab Use Only.
MMV1091186 (MMV 1091186) is an antimalarial compound that inhibit P. falciparum cytoplasmic isoleucyl tRNA synthetase (cIRS) with IC50 of 0.87 uM.
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MMV1091186 (MMV 1091186) is an antimalarial compound that inhibit P. falciparum cytoplasmic isoleucyl tRNA synthetase (cIRS) with IC50 of 0.87 uM.
MMV1091186 does not compete with ATP, ILE, or tRNA.
MMV1091186 has activity at the liver stage, asexual blood stage, and gametocyte stages aginst malaria life cycle with submicromolar activity.
MMV1091186 inhibits isoleucine transfer to tRNA with an IC50 of 23.8 uM.
| M.Wt | 362.48 | |
| Formula | C15H14N4OS3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Istvan ES, et al. Sci Transl Med. 2023 Mar 8;15(686):eadc9249.
2. Yevgeniya Antonova-Koch, et al. Science. 2018 Dec 7;362(6419):eaat9446.
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